Johnson and Stricker published an opinion piece in the Journal of Medical Ethics presenting their perspective on the 2008 agreement between the Infectious Diseases Society of America (IDSA) and the Connecticut Attorney General with regard to the 2006 IDSA treatment guideline for Lyme disease. Their writings indicate that these authors hold unconventional views of a relatively common tick-transmitted bacterial infection caused by the spirochete Borrelia burgdorferi. Therefore, it should come as no surprise that their opinions would clash with the IDSA's (...) evidence-based guidelines for the diagnosis and treatment of Lyme disease. Their allegations of conflict of interest against the IDSA resemble those made against the National Institutes of Health, the Food and Drug Administration and the Centers for Disease Control and Prevention in 2000, which were found to be baseless. It is the responsibility of all physicians and medical scientists to stand up to antiscientific, baseless and unethical attacks on those who support an evidence-based approach to caring for patients. (shrink)

This dual methods study explored one social studies teacher education program as it attempted to incorporate a cycle of practice-based teacher education into a methods course for the purpose of democratizing the teacher education experience. In addition to detailing the pedagogical decisions of the course instructor, researchers followed two social studies teacher candidates into their student teaching experience. Findings suggested that promoting social studies practice through a pedagogy of enactment is not enough. Rather, mentor teachers, course instructors, and teacher candidates (...) need to be aligned pedagogically as to the purposes and practices of social studies education. (shrink)

Hewitt's Conceptual Integrated Science is the most widely used textbook in Integrated Science courses. This course covers chemistry, physics, biology, earth science, and astronomy and is mostly taken by Elementary-Education Majors, i.e. future grade-school teachers who are required to take a survey-of-science course.

For several terms at Cambridge in 1939, Ludwig Wittgenstein lectured on the philosophical foundations of mathematics. A lecture class taught by Wittgenstein, however, hardly resembled a lecture. He sat on a chair in the middle of the room, with some of the class sitting in chairs, some on the floor. He never used notes. He paused frequently, sometimes for several minutes, while he puzzled out a problem. He often asked his listeners questions and reacted to their replies. Many meetings were (...) largely conversation. These lectures were attended by, among others, D. A. T. Gasking, J. N. Findlay, Stephen Toulmin, Alan Turing, G. H. von Wright, R. G. Bosanquet, Norman Malcolm, Rush Rhees, and Yorick Smythies. Notes taken by these last four are the basis for the thirty-one lectures in this book. The lectures covered such topics as the nature of mathematics, the distinctions between mathematical and everyday languages, the truth of mathematical propositions, consistency and contradiction in formal systems, the logicism of Frege and Russell, Platonism, identity, negation, and necessary truth. The mathematical examples used are nearly always elementary. (shrink)

The role of acetylcholinesterase (AChE) in neurotransmission is well known. But long before synapses are formed in vertebrates, AChE is expressed in young postmitotic neuroblasts that are about to extend the first long tracts. AChE histochemistry can thus be used to map primary steps of brain differentiation. Preceding an possibly inducing AChE in avian brains, the closely related butyrylcholinesterase (BChE) spatially fore-shadows AChE-positive cell areas and the course of their axons. In particular, before spinal motor axons grow, their corresponding rostral (...) sclerotomes and myotomes express BChE, and both their neuronal source and myotomal target cells express AChE. Since axon growth has been found inhibited by acetylcholine, it is postulated that both cholinetsreases can attract neurite growth cones by neutralizing the inhibitor. Thus, the early expression of both cholinesterases that is at least partially independent from classical cholinergic synaptogenesis, sheds new light on the developmental and medical significance of these enzymes. (shrink)

I examine whether it is possible for content relevant to a computer''s behavior to be carried without an explicit internal representation. I consider three approaches. First, an example of a chess playing computer carrying emergent content is offered from Dennett. Next I examine Cummins response to this example. Cummins says Dennett''s computer executes a rule which is inexplicitly represented. Cummins describes a process wherein a computer interprets explicit rules in its program, implements them to form a chess-playing device, then this (...) device executes the rules in a way that exhibits them inexplicitly. Though this approach is intriguing, I argue that the chess-playing device cannot exist as imagined. The processes of interpretation and implementation produce explicit representations of the content claimed to be inexplicit. Finally, the Chinese Room argument is examined and shown not to save the notion of inexplicit information. This means the strategy of attributing inexplicit content to a computer which is executing a rule, fails. (shrink)

Human neoplasms develop following the progressive accumulation of genetic and epigenetic alterations to oncogenes and tumor suppressor genes. These alterations confer a growth advantage to the cancer cell, leading to its clonal proliferation, invasion into surrounding tissues, and spread to distant organs. Genes that are altered in neoplasia affect three major biologic pathways that normally regulate cell growth and tissue homeostasis: the cell cycle, apoptosis, and differentiation. While each of these pathways can be defined by a unique set of molecular (...) events, they are not biologically separate. Rather, they function more as an integrated molecular network, and perturbations in one pathway can have profound consequences on another. Insights into what distinguishes the regulation of growth and differentiation in a normal cell versus a cancer cell have led to the development of novel anticancer therapies. BioEssays 24:83–90, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

Karl Rahner’s “world church” turns out to be a church of significant theological and cultural pluralism in which doctrine can sometimes strain to unify disparate elements. This article examines this problem in light of Rahner’s theory of doctrinal development. First, it examines the notion of doctrine itself, suggesting a pliable model inspired by usages of “dogma” in the early church which reflect both teaching and confession of faith. Second, Rahner’s theory of doctrinal development is discussed in light of Newman’s theory. (...) Rahner’s theory shares Newman’s emphasis on “mind” or “faith consciousness.” Although both attend to the historical mediations of revelation, the truth of doctrine remains at an ideational level, an expression of abstract truth. William Lynch’s notion of the imagination of faith and dogma as a poetic embodiment of truth offers an alternative model that accommodates fundamental insights of both Rahner and Newman. Finally, this article discusses how we can find a foundation for coherence amidst a pluralism of interpretations. The ancient regula fidei is invoked. Here, Rahner’s suggestion of short creedal formulae provides a possible modern equivalent. It is also itself an example of doctrinal development appropriate for situations within the world church in which Catholics now find themselves. (shrink)

As I put down my copy of The Making of Men and take up Volumes III and IV of Philosophy in Process, the period of the diary when Weiss was writing the book, I wondered whether the longer work showed more awareness of human weakness and disability. The philosophic program calls for the overcoming of bias and achievement of neutrality. Has Weiss ever admitted that men are sometimes born tired, suffer weaknesses, yield to the temptation of aiming low rather than (...) high, fail to put out much effort in capturing "the free energy" that Weiss ascribes to us all? If Weiss doesn't correct his account of human life that is too much based on his own great strengths, then the philosophy must be criticized as one-sided. Even if he has swept aside laziness as subhuman, much as a good teacher encourages students by expecting the superhuman and ignoring the subhuman, this practical encouragement cannot fully excuse theoretical failure in adequacy. For surely we who know Weiss know that he is not merely a performing artist who sometimes takes the classroom as a stage, but rather is a coach who knows how to bring the best performance out of his team of intellectual athletes. Most coaches expect to win every game and have a philosophy that never anticipates or prepares for failure. Is that why Weiss found himself so much at home in the world of Sport? (shrink)

Most literature on the ethics of global warming focuses on the obligations of industrialized states to reduce their emissions of greenhouse gases and to help poor countries do likewise. These books are no exception, arguing that the issue is a matter of international justice and equity.

The reputation of Rudolf Hermann Lotze was high in the philosophic world, especially the English-speaking philosophic world, during the period 1880–1920. One encyclopedia of the period says that “in the U. S. his influence is stronger in academic philosophy, perhaps, than that of any other author.” In typical histories of philosophy Lotze is counted among the great successors in the tradition of Kant and Hegel. I have elsewhere sought to explain the reasons for his great influence. Writers contemporary to Lotze (...) wanted first to classify him as an Herbartian, and in spite of his protests, he seemed some sort of Kantian or Hegelian. The character of his philosophy remained enigmatic, and he was sometimes called an “eclectic” since his philosophy contained aspects that reminded readers of some predecessor or other. But clearly he resisted the tendency to make all questions problems of knowledge: “The constant whetting of the knife is tedious, if it is not proposed to cut anything with it.” And clearly he is no Hegelian. He considered the rationalistic search for a single principle and a single method to have failed. German philosophy had failed to respect what is given in experience. Even in aesthetics, where surely one might be expected to attend to what the arts present for sensuous enjoyment, German intellectualism, to Lotze’s disgust, tended to use a deductive method. Santayana accused a priori German philosophers of “egotism”; he might have learned this from Lotze who found this same tradition marked by pretension. Only God could satisfy the program of Fichte. The demand of an all-embracing system is that it “make all particular parts of it pass before [us] in the majestic succession of an unbroken development!” Wrote Lotze, “It seemed to me that only a Spirit who stood in the centre of the universe which he himself had made could, with knowledge of the final aim which he had given his creation…” see the whole. Lotze’s kind of philosophy is professedly modest, nondogmatic, fallibilist. (shrink)